The hydrogen-poor, helium-rich, and carbon-rich character of the gas around R Coronae Borealis (RCB) stars has been suggested to be a site for formation of C60 molecules. This suggestion is not supported by observations reported here showing that infrared transitions of C60 are not seen in a large sample of RCB stars observed with the Infrared Spectrograph on the Spitzer Space Telescope. The infrared C60 transitions are seen, however, in emission and blended with polycyclic aromatic hydrocarbon (PAH) features in spectra of DY Cen and possibly also of V854 Cen, the two least hydrogen-deficient (hydrogen deficiency of only ~10-100) RCB stars. The speculation is offered that C60 (and the PAHs) in the moderately H-deficient circumstellar envelopes may be formed by the decomposition of hydrogenated amorphous carbon but fullerene formation is inefficient in the highly H-deficient environments of most RCBs.