Measurements of the 7Li/6Li ratio in the local interstellar medium (ISM) towards o Per and ζ Per by Knauth et al. (2000, AAA 073.131.129) show clouds with a range from near 2 (a value which points to GCR production by spallation or alpha + alpha to near 11 (the solar system value). These values can be very well accounted for within our model of general chemical enrichment of the Galaxy in which a key role is played by the continuing infall of metal-poor extragalactic gas to the Galactic plane, in the form of high-velocity clouds. Within this model, light nuclides are produced in the ISM, but destroyed in dense hot interstellar regions around massive stars, the process of which yields a differential depletion of 6Li relative to 7Li, which can vary on quite short-distance scales.