We report the discovery of a possible nova in M31 on a R band CCD image at JD 2453877.5 (2006, May 22.1 UT) with 18.7 mag (accuracy 0.1 mag). The image was obtained with the Wendelstein telescope (0.8 m, 1k x 1k CCD camera with 24mu sq. pixels). The position obtained for the nova candidate is RA(2000) = 00h 43m 11.81s, Dec(2000) = +41° 13' 44.7" with an accuracy of 0.1". At the position of the nova candidate no star brighter than 21.5 mag (1 sigma) was detected on 2006, May 12.2 UT on a Wendelstein R band image.