The spectra of two early B-type supergiant stars in the Sculptor spiral galaxy NGC 300 are analyzed by means of non-LTE line-blanketed unified model atmospheres, aimed at determining their chemical composition and the fundamental stellar and wind parameters. For the first time, a detailed chemical abundance pattern (He, C, N, O, Mg, and Si) is obtained for a B-type supergiant beyond the Local Group. The derived stellar properties are consistent with those of other Local Group B-type supergiants of similar types and metallicities. One of the stars shows a near solar metallicity, while the other one resembles more a SMC B supergiant. The effects of the lower metallicity can be detected in the derived wind momentum. Based on observations obtained at the ESO Very Large Telescope.