We emphasize in this paper the importance of the UV range for our knowledge of massive stars and the fundamental role played by past and present space-based UV capabilities (IUE, HST, FUSE and others). Based on a review of the work developed in the last years and the state of the art situation for quantitative spectroscopy of massive stars, we present crucial advances which could be addressed by hypothetical future space-based UV missions. Advantages and unique data that these missions could provide are explained in the context of our present knowledge and theories on massive stars in the Milky Way and nearby galaxies. It is argued that these studies are our key to a correct interpretation of observations of more distant objects.