The Extreme Universe Space Observatory (EUSO) Space Program on the International Space Station (ISS) is the first space-based mission worldwide in the field of Ultra High Energy Cosmic Rays (UHECR) and Extremely High Energy Cosmic Rays (EHECR) and will contribute to consolidate a new window in the astronomical observation at the highest energies never observed neither with ground-based nor space-based experiments. Currently the international groups working on ground-based UHECR experiments are organized in the Pierre Auger Collaboration (Argentina, South Hemisphere) and the
Telescope Array Collaboration (Utah, North Hemisphere). JEM-EUSO will pioneer from Space the observation from ISS (North & South Hemispheres) of the non thermal Universe and will provide a real breakthrough toward the understanding of the Extreme Universe at the highest energies never detected from Space. In this Severo Ochoa Seminar an overview of the JEM-EUSO Space Mission and the pathfinders currently being developed, EUSO-BALLOON of the French Space Agency (CNES) and MINI-EUSO (ISS) of the Russian Space Agency (Roscosmos) will be presented. Moreover the Spanish Contribution to this EUSO Program under a Coordinated Proposal of MINECO, that involves Instituto de Astrofísica de Canarias (IAC), Instituto Nacional de Técnica Aerospacial (INTA), Universidad Politécnica de Madrid (UPM), Univesidad de Leon (ULE) and Universidad de Alcalá (UAH) will be reviewed as well.