The 4-m aperture Advanced Technology Solar Telescope (ATST) is the next generation ground based solar telescope. In this paper we provide an overview of the ATST post-focus instrumentation. The majority of ATST instrumentation is located in an instrument Coude lab facility, where a rotating platform provides image de-rotation. A high order adaptive optics system delivers a corrected beam to the Coude lab facility. Alternatively, instruments can be mounted at Nasmyth or a small Gregorian area. For example, instruments for observing the faint corona preferably will be mounted at Nasmyth focus where maximum throughput is achieved. In addition, the Nasmyth focus has minimum telescope polarization and minimum stray light. We describe the set of first generation instruments, which include a Visible-Light Broadband Imager (VLBI), Visible and Near-Infrared (NIR) Spectropolarimeters, Visible and NIR Tunable Filters, a Thermal-Infrared Polarimeter & Spectrometer and a UV-Polarimeter. We also discuss unique and efficient approaches to the ATST instrumentation, which builds on the use of common components such as detector systems, polarimetry packages and various opto-mechanical components.