The gamma radiolysis of fullerene C-60 dispersed in H2O, H2O/NH3, H2O/methanol and H2O/NH3/methanol was studied at 250 and 500 kGy. It was found that C-60 originally insoluble in the above mentioned hosting matrix became soluble as a consequence of multiple hydroxylation and oxidation reaction produced by the free radicals generated by the radiolysis of the hosting matrix. The changes undergone by C-60 were studied by infrared spectroscopy (FT-IR) and by electronic absorption spectroscopy. The astrochemical consequences of the present study are that C-60 ejected in the interstellar medium for instance from protoplanetary and planetary nebulae can condense together with water and other ices in dense molecular clouds. Under the action of high energy radiation C-60 reacts with the free radicals generated from the matrix where it is embedded it is solubilized and consequently its carbon content becomes available for further abiotic processes of synthesis of molecules of astrobiological interest. The behavior of C-60 appears comparable to that of common PAHs which are also hydroxylated and oxidized under similar conditions.