This talk will be dedicated to luminous (LBol~1E47 erg/s),
high-redshift quasars, which are ideal targets to investigate (i) feedback
from SMBHs, and (ii) the early growth phases of giant galaxies. I will
present evidence of  SMBH-driven outflows  at all Cosmic epochs, back to
the early Universe. These outflows involve all gas phases (molecular,
neutral, ionised) and extend on nuclear to galactic and circum-galactic
scales. I will report on the first systematic study of the molecular gas
properties in the host-galaxies of the most luminous quasars, fundamental
to probe the impact of SMBH feedback on the host-galaxy evolution. I will
show that luminous quasars pinpoint high-density sites where giant galaxies
assemble, and I will discuss the major contribution of mergers to the final
galaxy mass. To this aim, I will present a wealth of multi-wavelength (UV
to sub-millimeter) observations from the WISE/SDSS hyper-luminous quasars
survey  at z~2-5 (WISSH), and recent results from the ESO large program
XQR-30, the Ultimate X-SHOOTER Legacy Survey of Quasars at the Reionization
epoch.